Molecular Imaging For Whole Body Visualisation Of Diseases

H2020-MSCA-IEF-2019

Dr. Affinito studied Pharmacy at Federico II University of Naples, Italy. She obtained her PhD, from the same university, in Molecular Medicine and Medical Biotechnology in 2018. Dr. Affinito has worked in Prof Condorelli's laboratories where she held her two postdoctoral positions. Dr. Affinito’s attitude in different approaches encouraged her to participate in the Erasmus Plus Program and won a 3-month fellowship of Prof Patrick Arbuthnot's lab - Antiviral Gene Therapy Research Unit - at the University of the Witwatersrand in Johannesburg (South Africa). Dr. Affinito’s main research interest is in the development of RNA aptamers as an innovative therapeutic and diagnostic tool in several types of cancers. Indeed, she has recently won a Marie Skłodowska-Curie Individual Fellowships 2020, which is focused on an innovative tool to detect Glioblastoma exosomes on liquid biopsy-based on synthetic aptamer.

a.affinito@percuros.nl

A40s target, EphA2, is loaded in exosomes released by GSCs. A40s is able to bind EphA2-positive exosomes in cell culture media and in blood samples, distinguishing GBM exosomes from normal exosomes.

Scientific articles published or submitted by Dr Affinito

Type

Description

Status

Date

Impact and Citation

Research Article

Selection of RNA aptamers targeting hypoxia in cancer

Accepted

to be published

Impact: 6.11

Citation: -

Research Article

Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study doi.org/10.3390/ijms23073989

Published

2022 Apr 3

Impact: 6.21

Citation: 1

Research Article

Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer doi.org/10.1016/j.omtn.2022.02.013

Published

2022 Feb 22

Impact: 8.86

Citation: 2

Research Article

Urinary Dickkopf-3 and Contrast- Associated Kidney Damage doi.org/10.1016/j.jacc.2021.03.330

Published

2021 Jun 1

Impact: 27.20

Citation: 8

Systematic Review

The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature doi.org/10.3390/cancers12082173

Published

2020 Aug 5

Impact: 6.64

Citation: 11

Research Article

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer doi.org/10.3390/ph13080172

Published

2020 Jul 30

Impact: 5.68

Citation: -

 

  This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 891551