Molecular Imaging For Whole Body Visualisation Of Diseases

Publications

Selection of Key Publications From Group Members:

  1. Zerrillo L, Gupta K, Lefeber F, Da Silva CG, Galli F, Chan A, et al. Novel Fluorinated Poly (Lactic-Co-Glycolic acid) (PLGA) and Polyethylene Glycol (PEG) Nanoparticles for Monitoring and Imaging in Osteoarthritis. Pharmaceutics. 2021;13(2).
  2. Zambito G, Hall MP, Wood MG, Gaspar N, Ridwan Y, Stellari FF, et al. Red-shifted click beetle luciferase mutant expands the multicolor bioluminescent palette for deep tissue imaging. iScience. 2021;24(1):101986.
  3. Sier VQ, de Vries MR, van der Vorst JR, Vahrmeijer AL, van Kooten C, Cruz LJ, et al. Cell-Based Tracers as Trojan Horses for Image-Guided Surgery. Int J Mol Sci. 2021;22(2).
  4. Rijs Z, Shifai AN, Bosma SE, Kuppen PJK, Vahrmeijer AL, Keereweer S, et al. Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas: A Systematic Review. Cancers (Basel). 2021;13(3).
  5. Oliveira A, Zerillo L, Cruz LJ, Schomann T, Chan AB, de Carvalho TG, et al. Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer. Mater Sci Eng C Mater Biol Appl. 2021;120:111678.
  6. Gaspar N, Walker JR, Zambito G, Marella-Panth K, Lowik C, Kirkland TA, et al. Evaluation of NanoLuc substrates for bioluminescence imaging of transferred cells in mice. J Photochem Photobiol B. 2021;216:112128.
  7. Cruz LJ, van Dijk T, Vepris O, Li T, Schomann T, Baldazzi F, et al. PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells. Biomaterials. 2021;268:120580.
  8. Cavalcante RS, Ishikawa U, Silva ES, Silva Junior AA, Araujo AA, Cruz LJ, et al. M2 TAM-associated STAT3/NF-kappaB signalling suppression as major target of immunomodulatory therapy with PLGA-based nanocarriers and anti-PD-L1 in breast cancer. Br J Pharmacol. 2021.
  9. Baart VM, van der Horst G, Deken MM, Bhairosingh SS, Schomann T, Sier VQ, et al. A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma. Eur J Cancer. 2021;146:11-20.
  10. Arena R, Bisogno S, Gasior L, Rudnicka J, Bernhardt L, Haaf T, et al. Lipid droplets in mammalian eggs are utilized during embryonic diapause. Proc Natl Acad Sci U S A. 2021;118(10).
  11. Zambito G, Gaspar N, Ridwan Y, Hall MP, Shi C, Kirkland TA, et al. Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging. Mol Imaging Biol. 2020;22(6):1523-31.
  12. Schomann T, Iljas JD, Que I, Li Y, Suidgeest E, Cruz LJ, et al. Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury. Cell Tissue Res. 2020;381(1):55-69.
  13. Roscigno G, Scognamiglio I, Ingenito F, Chianese RV, Palma F, Chan A, et al. Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment. Cancers (Basel). 2020;12(12).
  14. Roscigno G, Cirella A, Affinito A, Quintavalle C, Scognamiglio I, Palma F, et al. miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment. Int J Mol Sci. 2020;21(7).
  15. Potabattula R, Zacchini F, Ptak GE, Dittrich M, Muller T, El Hajj N, et al. Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline. Aging Cell. 2020;19(8):e13181.
  16. Petho Z, Najder K, Carvalho T, McMorrow R, Todesca LM, Rugi M, et al. pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology. Cancers (Basel). 2020;12(9).
  17. Palma F, Affinito A, Nuzzo S, Roscigno G, Scognamiglio I, Ingenito F, et al. miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer. Cancer Gene Ther. 2020.
  18. Nuzzo S, Brancato V, Affinito A, Salvatore M, Cavaliere C, Condorelli G. The Role of RNA and DNA Aptamers in Glioblastoma Diagnosis and Therapy: A Systematic Review of the Literature. Cancers (Basel). 2020;12(8).
  19. Lara P, Chan AB, Cruz LJ, Quest AFG, Kogan MJ. Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues. Pharmaceutics. 2020;12(11).
  20. Houvast RD, Vankemmelbeke M, Durrant LG, Wuhrer M, Baart VM, Kuppen PJK, et al. Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging. Cancers (Basel). 2020;12(12).
  21. Houvast RD, Baart VM, Bhairosingh SS, Cordfunke RA, Chua JX, Vankemmelbeke M, et al. Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study. Mol Imaging Biol. 2020;22(6):1511-22.
  22. Gaspar N, Zambito G, Dautzenberg IJC, Cramer SJ, Hoeben RC, Lowik C, et al. NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice-A Novel in Vivo Imaging Platform. Int J Mol Sci. 2020;21(16).
  23. de Muijnck C, van Gorkom Y, van Duijvenvoorde M, Eghtesadi M, Dekker-Ensink G, Bhairosingh SS, et al. Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer. Pharmaceuticals (Basel). 2020;13(8).nuzzo
  24. de Araujo Junior RF, Eich C, Jorquera C, Schomann T, Baldazzi F, Chan AB, et al. Ceramide and palmitic acid inhibit macrophage-mediated epithelial-mesenchymal transition in colorectal cancer. Mol Cell Biochem. 2020;468(1-2):153-68.
  25. de Araujo Junior RF, Eich C, Jorquera C, Schomann T, Baldazzi F, Chan AB, et al. Correction to: Ceramide and palmitic acid inhibit macrophage-mediated epithelial-mesenchymal transition in colorectal cancer. Mol Cell Biochem. 2020;469(1-2):179-80.
  26. Chung CK, Garcia-Couce J, Campos Y, Kralisch D, Bierau K, Chan A, et al. Doxorubicin Loaded Poloxamer Thermosensitive Hydrogels: Chemical, Pharmacological and Biological Evaluation. Molecules. 2020;25(9).
  27. Chung CK, Fransen MF, van der Maaden K, Campos Y, Garcia-Couce J, Kralisch D, et al. Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies. J Control Release. 2020;323:1-11.
  28. Carvalho Vasconcelos R, Ferreira C, de Araujo EM, Motta F, Bomio M, de Araujo Junior RF, et al. Zirconia/hydroxyapatite (80/20) scaffold repair in critical size calvarial defect increased FGF-2, osteocalcin and OPG immunostaining and IL-10 levels. Am J Transl Res. 2020;12(6):2439-50.
  29. Campos Y, Sola FJ, Almirall A, Fuentes G, Eich C, Que I, et al. Design, construction, and biological testing of an implantable porous trilayer scaffold for repairing osteoarthritic cartilage. J Tissue Eng Regen Med. 2020;14(2):355-68.
  30. Baart VM, Houvast RD, de Geus-Oei LF, Quax PHA, Kuppen PJK, Vahrmeijer AL, et al. Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer. EJNMMI Res. 2020;10(1):87.
  31. AL CdSLO, Araujo Junior RF, Gomes de Carvalho T, A BC, Schomann T, Tamburini F, et al. Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer. Pharmaceutics. 2020;12(2).
  32. Affinito A, Quintavalle C, Esposito CL, Roscigno G, Giordano C, Nuzzo S, et al. Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells. Mol Ther Nucleic Acids. 2020;20:176-85.
  33. Zerrillo L, Que I, Vepris O, Morgado LN, Chan A, Bierau K, et al. pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis. J Control Release. 2019;309:265-76.
  34. Nuzzo S, Roscigno G, Affinito A, Ingenito F, Quintavalle C, Condorelli G. Potential and Challenges of Aptamers as Specific Carriers of Therapeutic Oligonucleotides for Precision Medicine in Cancer. Cancers (Basel). 2019;11(10).
  35. Kenkhuis B, Jonkman LE, Bulk M, Buijs M, Boon BDC, Bouwman FH, et al. 7T MRI allows detection of disturbed cortical lamination of the medial temporal lobe in patients with Alzheimer's disease. Neuroimage Clin. 2019;21:101665.
  36. Ingenito F, Roscigno G, Affinito A, Nuzzo S, Scognamiglio I, Quintavalle C, et al. The Role of Exo-miRNAs in Cancer: A Focus on Therapeutic and Diagnostic Applications. Int J Mol Sci. 2019;20(19).
  37. Green C, Sydow A, Vogel S, Anglada-Huguet M, Wiedermann D, Mandelkow E, et al. Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer's disease mouse model. Mol Neurodegener. 2019;14(1):13.
  38. Green C, Minassian A, Vogel S, Diedenhofen M, Wiedermann D, Hoehn M. Persistent Quantitative Vitality of Stem Cell Graft Is Necessary for Stabilization of Functional Brain Networks After Stroke. Front Neurol. 2019;10:335.
  39. Gaspar N, Zambito G, Lowik C, Mezzanotte L. Active Nano-targeting of Macrophages. Curr Pharm Des. 2019;25(17):1951-61.
  40. Garcia-Couce J, Almirall A, Fuentes G, Kaijzel E, Chan A, Cruz LJ. Targeting Polymeric Nanobiomaterials as a Platform for Cartilage Tissue Engineering. Curr Pharm Des. 2019;25(17):1915-32.
  41. Garcia VB, de Carvalho TG, da Silva Gasparotto LH, da Silva HFO, de Araujo AA, Guerra GCB, et al. Environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for inflammation-induced cancer imaging. Nanoscale Res Lett. 2019;14(1):166.
  42. Feng Y, Wu Y, Zuo J, Tu L, Que I, Chang Y, et al. Assembly of upconversion nanophotosensitizer in vivo to achieve scatheless real-time imaging and selective photodynamic therapy. Biomaterials. 2019;201:33-41.
  43. Da Silva CG, Camps MGM, Li T, Chan AB, Ossendorp F, Cruz LJ. Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines. Biomaterials. 2019;220:119417.
  44. Collmann FM, Pijnenburg R, Hamzei-Taj S, Minassian A, Folz-Donahue K, Kukat C, et al. Individual in vivo Profiles of Microglia Polarization After Stroke, Represented by the Genes iNOS and Ym1. Front Immunol. 2019;10:1236.
  45. Affinito A, Quintavalle C, Esposito CL, Roscigno G, Vilardo C, Nuzzo S, et al. The Discovery of RNA Aptamers that Selectively Bind Glioblastoma Stem Cells. Mol Ther Nucleic Acids. 2019;18:99-109.
  46. Vogel S, Aswendt M, Nelles M, Henn N, Schneider G, Hoehn M. Initial graft size and not the innate immune response limit survival of engrafted neural stem cells. J Tissue Eng Regen Med. 2018;12(3):784-93.
  47. van Midwoud PM, Sandker M, Hennink WE, de Leede LGJ, Chan A, Weinans H. In vivo pharmacokinetics of celecoxib loaded endcapped PCLA-PEG-PCLA thermogels in rats after subcutaneous administration. Eur J Pharm Biopharm. 2018;131:170-7.
  48. Stammes MA, Bugby SL, Porta T, Pierzchalski K, Devling T, Otto C, et al. Modalities for image- and molecular-guided cancer surgery. Br J Surg. 2018;105(2):e69-e83.
  49. Slooter MD, Handgraaf HJM, Boonstra MC, van der Velden LA, Bhairosingh SS, Que I, et al. Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase. Oral Oncol. 2018;78:1-7.
  50. Schomann T, Ramekers D, de Groot J, van der Ploeg CH, Hendriksen FGJ, Bohringer S, et al. Ouabain Does Not Induce Selective Spiral Ganglion Cell Degeneration in Guinea Pigs. Biomed Res Int. 2018;2018:1568414.
  51. Napp J, Stammes MA, Claussen J, Prevoo H, Sier CFM, Hoeben FJM, et al. Fluorescence- and multispectral optoacoustic imaging for an optimized detection of deeply located tumors in an orthotopic mouse model of pancreatic carcinoma. Int J Cancer. 2018;142(10):2118-29.
  52. Mahinrad S, Bulk M, van der Velpen I, Mahfouz A, van Roon-Mom W, Fedarko N, et al. Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients. Front Neurosci. 2018;12:864.
  53. Kogelman B, Khmelinskii A, Verhaart I, Vliet LV, Bink DI, Aartsma-Rus A, et al. Influence of full-length dystrophin on brain volumes in mouse models of Duchenne muscular dystrophy. PLoS One. 2018;13(3):e0194636.
  54. Kleinovink JW, Mezzanotte L, Zambito G, Fransen MF, Cruz LJ, Verbeek JS, et al. A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function. Front Immunol. 2018;9:3097.
  55. Green C, Minassian A, Vogel S, Diedenhofen M, Beyrau A, Wiedermann D, et al. Sensorimotor Functional and Structural Networks after Intracerebral Stem Cell Grafts in the Ischemic Mouse Brain. J Neurosci. 2018;38(7):1648-61.
  56. de Carvalho TG, Garcia VB, de Araujo AA, da Silva Gasparotto LH, Silva H, Guerra GCB, et al. Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats. Int J Pharm. 2018;548(1):1-14.
  57. De Araujo RF, Jr., Pessoa JB, Cruz LJ, Chan AB, De Castro Miguel E, Cavalcante RS, et al. Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins. Int J Oncol. 2018;52(1):189-200.
  58. Collmann FM, Pijnenburg R, Schneider G, Schafer C, Folz-Donahue K, Kukat C, et al. Imaging Reporter Strategy to Monitor Gene Activation of Microglia Polarisation States under Stimulation. J Neuroimmune Pharmacol. 2018;13(3):371-82.
  59. Chung CK, Da Silva CG, Kralisch D, Chan A, Ossendorp F, Cruz LJ. Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences. J Control Release. 2018;285:56-66.
  60. Bulk M, van der Weerd L, Breimer W, Lebedev N, Webb A, Goeman JJ, et al. Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects. Sci Rep. 2018;8(1):6898.
  61. Bulk M, Kenkhuis B, van der Graaf LM, Goeman JJ, Natte R, van der Weerd L. Postmortem T2*- Weighted MRI Imaging of Cortical Iron Reflects Severity of Alzheimer's Disease. J Alzheimers Dis. 2018;65(4):1125-37.
  62. Bulk M, Abdelmoula WM, Nabuurs RJA, van der Graaf LM, Mulders CWH, Mulder AA, et al. Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease. Neurobiol Aging. 2018;62:231-42.
  63. van Duijn S, Bulk M, van Duinen SG, Nabuurs RJA, van Buchem MA, van der Weerd L, et al. Cortical Iron Reflects Severity of Alzheimer's Disease. J Alzheimers Dis. 2017;60(4):1533-45.
  64. Stammes MA, Prevoo HA, Ter Horst MC, Groot SA, Van de Velde CJ, Chan AB, et al. Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery. Int J Mol Sci. 2017;18(2).
  65. Sandker MJ, Duque LF, Redout EM, Chan A, Que I, Lowik C, et al. Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers. Acta Biomater. 2017;48:401-14.
  66. Mulder IA, Khmelinskii A, Dzyubachyk O, de Jong S, Wermer MJH, Hoehn M, et al. MRI Mouse Brain Data of Ischemic Lesion after Transient Middle Cerebral Artery Occlusion. Front Neuroinform. 2017;11:51.
  67. Mulder IA, Khmelinskii A, Dzyubachyk O, de Jong S, Rieff N, Wermer MJ, et al. Automated Ischemic Lesion Segmentation in MRI Mouse Brain Data after Transient Middle Cerebral Artery Occlusion. Front Neuroinform. 2017;11:3.
  68. Mezzanotte L, Iljas JD, Que I, Chan A, Kaijzel E, Hoeben R, et al. Optimized Longitudinal Monitoring of Stem Cell Grafts in Mouse Brain Using a Novel Bioluminescent/Near Infrared Fluorescent Fusion Reporter. Cell Transplant. 2017;26(12):1878-89.
  69. Kaijzel EL, van Beek ER, Stammes MA, Que I, Chan AB, Lowik C, et al. Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic Approaches. Curr Pharm Des. 2017;23(13):1909-15.
  70. In't Veld RH, Da Silva CG, Kaijzel EL, Chan AB, Cruz LJ. The Potential of Nano-Vehicle Mediated Therapy in Vasculitis and Multiple Sclerosis. Curr Pharm Des. 2017;23(13):1985-92.
  71. Boonstra MC, Van Driel P, Keereweer S, Prevoo H, Stammes MA, Baart VM, et al. Preclinical uPAR-targeted multimodal imaging of locoregional oral cancer. Oral Oncol. 2017;66:1-8.
  72. Adamczak J, Aswendt M, Kreutzer C, Rotheneichner P, Riou A, Selt M, et al. Neurogenesis upregulation on the healthy hemisphere after stroke enhances compensation for age-dependent decrease of basal neurogenesis. Neurobiol Dis. 2017;99:47-57.
  73. van Driel PB, Boonstra MC, Prevoo HA, van de Giessen M, Snoeks TJ, Tummers QR, et al. EpCAM as multi-tumour target for near-infrared fluorescence guided surgery. BMC Cancer. 2016;16(1):884.
  74. van Driel P, Boonstra MC, Slooter MD, Heukers R, Stammes MA, Snoeks TJA, et al. EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer. J Control Release. 2016;229:93-105.
  75. Stammes MA, Maeda A, Bu J, Scollard DA, Kulbatski I, Medeiros PJ, et al. The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death. Front Oncol. 2016;6:221.
  76. Stammes MA, Knol-Blankevoort VT, Cruz LJ, Feitsma HR, Mezzanotte L, Cordfunke RA, et al. Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging. Mol Imaging Biol. 2016;18(6):905-15.
  77. Selt M, Tennstaedt A, Beyrau A, Nelles M, Schneider G, Lowik C, et al. In Vivo Non-Invasive Tracking of Macrophage Recruitment to Experimental Stroke. PLoS One. 2016;11(6):e0156626.
  78. Mulder IA, Esteve C, Wermer MJ, Hoehn M, Tolner EA, van den Maagdenberg AM, et al. Funnel-freezing versus heat-stabilization for the visualization of metabolites by mass spectrometry imaging in a mouse stroke model. Proteomics. 2016;16(11-12):1652-9.
  79. Lucassen EA, Coomans CP, van Putten M, de Kreij SR, van Genugten JH, Sutorius RP, et al. Environmental 24-hr Cycles Are Essential for Health. Curr Biol. 2016;26(14):1843-53.
  80. Kleinovink JW, van Driel PB, Snoeks TJ, Prokopi N, Fransen MF, Cruz LJ, et al. Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors. Clin Cancer Res. 2016;22(6):1459-68.
  81. Hamzei Taj S, Kho W, Riou A, Wiedermann D, Hoehn M. MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia. Biomaterials. 2016;91:151-65.
  82. Hamzei Taj S, Kho W, Aswendt M, Collmann FM, Green C, Adamczak J, et al. Dynamic Modulation of Microglia/Macrophage Polarization by miR-124 after Focal Cerebral Ischemia. J Neuroimmune Pharmacol. 2016;11(4):733-48.
  83. Hammelrath L, Skokic S, Khmelinskii A, Hess A, van der Knaap N, Staring M, et al. Morphological maturation of the mouse brain: An in vivo MRI and histology investigation. Neuroimage. 2016;125:144-52.
  84. Cruz LJ, Stammes MA, Que I, van Beek ER, Knol-Blankevoort VT, Snoeks TJA, et al. Effect of PLGA NP size on efficiency to target traumatic brain injury. J Control Release. 2016;223:31-41.
  85. Xie B, Stammes MA, van Driel PB, Cruz LJ, Knol-Blankevoort VT, Lowik MA, et al. Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models. Oncotarget. 2015;6(36):39036-49.
  86. Schoeman MA, Moester MJ, Oostlander AE, Kaijzel EL, Valstar ER, Nelissen RG, et al. Inhibition of GSK3beta Stimulates BMP Signaling and Decreases SOST Expression Which Results in Enhanced Osteoblast Differentiation. J Cell Biochem. 2015;116(12):2938-46.
  87. Schaafsma BE, van de Giessen M, Charehbili A, Smit VT, Kroep JR, Lelieveldt BP, et al. Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer. Clin Cancer Res. 2015;21(3):577-84.
  88. Janmaat CJ, de Rooij KE, Locher H, de Groot SC, de Groot JC, Frijns JH, et al. Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins. PLoS One. 2015;10(12):e0145235.
  89. Boonstra MC, van Driel PB, van Willigen DM, Stammes MA, Prevoo HA, Tummers QR, et al. uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery. Oncotarget. 2015;6(16):14260-73.
  90. Aswendt M, Henn N, Michalk S, Schneider G, Steiner MS, Bissa U, et al. Novel bimodal iron oxide particles for efficient tracking of human neural stem cells in vivo. Nanomedicine (Lond). 2015;10(16):2499-512.
  91. Voorneveld PW, Kodach LL, Jacobs RJ, Liv N, Zonnevylle AC, Hoogenboom JP, et al. Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK. Gastroenterology. 2014;147(1):196-208 e13.
  92. van Driel PB, van der Vorst JR, Verbeek FP, Oliveira S, Snoeks TJ, Keereweer S, et al. Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody. Int J Cancer. 2014;134(11):2663-73.
  93. Moester MJ, Schoeman MA, Oudshoorn IB, van Beusekom MM, Mol IM, Kaijzel EL, et al. Validation of a simple and fast method to quantify in vitro mineralization with fluorescent probes used in molecular imaging of bone. Biochem Biophys Res Commun. 2014;443(1):80-5.
  94. Dzyubachyk O, Khmelinskii A, Plenge E, Kok P, Snoeks TJ, Poot DH, et al. Interactive local super-resolution reconstruction of whole-body MRI mouse data: a pilot study with applications to bone and kidney metastases. PLoS One. 2014;9(9):e108730.
  95. Chan A, van Bezooijen RL, Lowik CW. A new paradigm in the treatment of osteoporosis: Wnt pathway proteins and their antagonists. Curr Opin Investig Drugs. 2007;8(4):293-8.
  96. Kaijzel EL, van Heijningen PM, Wielopolski PA, Vermeij M, Koning GA, van Cappellen WA, Que I, Chan A, Dijkstra J, Ramnath NW, Hawinkels LJ, Bernsen MR, Löwik CW, Essers J. Multimodality imaging reveals a gradual increase in matrix metalloproteinase activity at aneurysmal lesions in live fibulin-4 mice. Circ Cardiovasc Imaging. 2010: 3(5):567-77. Epub 2010 Jun 30.
  97. Keereweer S, Kerrebijn JD, van Driel PB, Xie B, Kaijzel EL, Snoeks TJ, Que I, Hutteman M, van der Vorst JR, Mieog JS, Vahrmeijer AL, van de Velde CJ, Baatenburg de Jong RJ, Löwik CW. Optical image-guided surgery--where do we stand?
    Mol Imaging Biol. 2011 Apr;13(2):199-207. Review
  98. van der Vorst JR, Hutteman M, Mieog JS, de Rooij KE, Kaijzel EL, Löwik CW, Putter H, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL. Near-Infrared Fluorescence Imaging of Liver Metastases in Rats using Indocyanine Green. J Surg Res. 2011 Feb 2. 
  99. Snoeks TJ, Mol IM, Que I, Kaijzel EL, Löwik CW. 2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo. Mol Cancer Ther. 2011 May;10(5):874-82.
  100. Keereweer S, Mieog JS, Mol IM, Van Driel PB, Snoeks TJ, Baatenburg de Jong RJ, Vahrmeijer AL, Kerrebijn JD, Löwik CW. Detection of oral squamous cell carcinoma and cervical lymph node metastasis using activatable near-infrared fluorescence agents. Arch Otolaryngol Head Neck Surg. 2011 Jun;137(6):609-15
  101. Keereweer S, Mol IM, Kerrebijn JD, Van Driel PB, Xie B, Baatenburg de Jong RJ, Vahrmeijer AL, Löwik CW. Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer. J Surg Oncol. 2011 Sep 27.
  102. Keereweer S, Kerrebijn JD, Mol IM, Mieog JS, Van Driel PB, Baatenburg de Jong RJ, Vahrmeijer AL, Löwik CW. Optical imaging of oral squamous cell carcinoma and cervical lymph node metastasis. Head Neck. 2011: Oct 10
  103. Keereweer S, Mol IM, Vahrmeijer AL, Van Driel PB, Baatenburg de Jong RJ, Kerrebijn JD, Löwik CW. Dual wavelength tumor targeting for detection of hypopharyngeal cancer using near-infrared optical imaging in an animal model. Int
    J Cancer. 2012 Jan 10. 
  104. Keereweer S, Sterenborg HJ, Kerrebijn JD, Van Driel PB, de Jong RJ, Löwik CW. Image-guided surgery in head and neck cancer: current practice and future directions of optical imaging. Head Neck. 2012 Jan;34(1):120-6
  105. Xie BW, Mol IM, Keereweer S, van Beek ER, Que I, Snoeks TJA, Chan A, Kaijzel  EL, Löwik CWGM. Dual-Wavelength Imaging of tumor progression by activatable and targeting near infrared fluorescent probes in a bioluminescent breast cancer model. PLoS One. 2012;7(2):e31875. Epub 2012 Feb 13
  106. Chan AB, Kaijzel EL, Löwik CWGM, Essers J. Molecular Imaging of Inflammation in Aortic Aneurysmal Disease. Curr Cardiovasc Imaging Rep. 2012: 5(1):11-18. Epub 2011 Nov 5
  107. Hollestelle A, Peeters JK, Smid M, Timmermans M, Verhoog LC, Westenend PJ, Heine AA, Chan A, Sieuwerts AM, Wiemer EA, Klijn JG, van der Spek PJ, Foekens JA, Schutte M, den Bakker MA, Martens JW. Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer. Breast Cancer Res Treat. 2013 Jan 22.
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